As prophylactic treatment of migraine.
In appetite loss of somatic or psychogenic origin in underweight patients.
As an adjuvant to treatment of the underlying condition, such as infectious or parasitic diseases (including during convalescence), chronic diarrhoea, anorexia nervosa.
Depressive states in the elderly and mood disturbances in the elderly.
Dosage & Administration
For migraine: 1.5mg at night or 0.5 mg three times daily, adjusted according to response within the usual range 0.5-3 mg daily, maximum single dose 3 mg, maximum daily does 4.5 mg.
Children: Low starting doses, gradually increasing to a mean maintenance dosage of 0.025mg/kg/day in 2-3 divided doses, or as directed by the physician.
Adults: Starting dose of 0.5 mg/day, gradually increasing to 0.5 mg three times daily.
Mood disturbances in the elderly: A starting of 0.5 mg/day is recommended increasing-preferably in steps of 0.5 mg daily until the optimum level is reached. Doses upto 12 mg/day are well tolerated.
Antimuscarinic effects- drowsiness, increased appetite, weight gain. Occasionally nausea, dizziness, CNS stimulation, may occur in children.