1. Anxiety disorder
2. Anxiety associated with depression
3. Panic disorder, with or without agoraphobia
Dosage & Administration
Xolam XR Tablets may be administered once daily, preferably in the morning. The tablets should be taken intact; they should not be chewed, crushed or broken. Xolam XR should be initiated with a dose of 0.5 mg to 1 mg once daily. Depending on the response, the dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg/day. The suggested total daily dose ranges from 3 to 6 mg/day for most patients but some patients may require doses as much as 10 mg/day.
In elderly patients & in patients with advanced liver disease or debilitating disease, the usual starting dose of Xolam XR is 0.5 mg once daily.
Switch from Alprazolam (Immediate-release) tablets to Xolam XR tablets :
Patients who are currently being treated with divided doses of Alprazolam (Immediate-release) tablets, for example 3 to 4 times a day, may be switched to Xolam XR (Alprazolam XR) tablets at the same total daily dose taken once daily.
1. Acute narrow angle glaucoma
2. Acute pulmonary insufficiency
3. With ketoconazole and itraconazole
4. In known hypersensitivity to this drug or other benzodiazepines
Warning & Precautions
Prolonged use of Alprazolam may cause the development of physical dependence, tolerance. As a result benzodiazepines withdrawal symptoms may occur during rapid dose reduction or sudden cessation of therapy after long term treatment. Therefore, the dosage of Xolam XR should be reduced or discontinued gradually. It is suggested that the daily dosage be decreased by no more than 0.5 mg every three(3) days. Some patients may require an even slower dosage reduction.
In general the side effect profile of Alprazolam is benign. Some side effects may disappear with continued treatment. However, the most frequent side effects are fatigue, somnolence, muscle weakness, ataxia, dizziness, louboutin heels, impairment of memory, confusion etc.