Dosage & Administration
- 1-6 months: 10 mg/Kg/day
- 6 months-1 year: 15 mg/Kg/day
- 1-9 years: 24 mg/Kg/day
- 10-16 years: 18 mg/Kg/day
- Adults: 10-15 mg/Kg/day
Theophylline should not be administered concurrently with other xanthine. Use with caution in patients with hypoxemia, hypertension, or those with history of peptic ulcer. Do not attempt to maintain any dose that is not tolerated.
Gastrointestinal: Nausea, vomiting, epigastric pain and diarrhoea.
Central nervous system: Headache, irritability, restlessness, insomnia, muscles twitching.
Cardiovascular: Palpitation, tachycardia, hypotension. circulatory failure.
Renal: Potentiation of diuresis.
Others: Alopecia, hyperglycemia, rash etc.
Pregnancy & Lactation
Nursing mother: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants. Serious adverse effects in the infant are unlikely unless the mother has toxic serum Theophylline concentrations.