Dosage & Administration
Coumarin derivatives: Slightly enhance the anticoagulant effect of Warfarin (mean changes in p rothrombin time less than two seconds) in normal volunteers maintained in a state of low therapeutic anticoagulation.
Others: In clinical studies, Simvastatin was used concomitantly with ACE inhibitors, beta-blockers, calcium channel blockers, diuretics and NSAIDs without evidence of clinically significant adverse interactions.
- Active liver disease
- Pregnant and breast feeding mother
- Women of child bearing age unless they have been adequately protected by contraception
- Hypersensitivity to any component of the preparation
- Patients with the homozygous familial hypercholesterolemia who have a complete absence of LDL receptors