Frusemide & Spironolactone combination is indicated in-
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis, with collection of fluid in the abdominal cavity (ascites)
- Swelling due to excess fluid retention (edema)
- Resistant edema associated with secondary hyperaldosteronism
Dosage & Administration
Furosemide 20 and spironolactone 50 mg: 1 to 4 tablets daily according to the patient’s response.
Furosemide 40 and spironolactone 50 mg: For previously stabilized patients 1 to 2 tablets daily, orally.
Pregnancy & Lactation
Pregnancy: Spironolactone and its metabolites may cross the placental barrier. The use of spironolactone in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the mother and fetus. Animal teratology studies indicate that Furosemide may cause fetal abnormalities. Therefore, Furosemide should only be used in women in child bearing age when appropriate contraceptive measures are taken or if the potential benefits justify the potential risks to the fetus.
Lactation: Metabolites of Spironolactone have been detected in breast milk. If use of Spironolactone is considered essential, an alternative method of infant feeding should be instituted. Furosemide is excreted in breast milk and breast-feeding should be discontinued if treatment is essential.