Escitalopram Oxalate is indicated for the treatment of major depressive
Elderly : A single oral dose of 10 mg/day is the recommended dose for most
elderly patients. Administered in excess recommended dose has not been
Pediatric Use : Safety and effectiveness in children below the age of 18 years
have not been established.
CONTRAINDICATION AND PRECAUTION
Concomitant use in patients taking monoamine oxidase inhibitor is
contraindicated. This is contraindicatd in patients with known
hypersensitivity to escitalopram oxalate or citalopram.
If a patient enters a manic phase, Escitalopram Oxalate should be
As with all drugs effective in the treatment of major depressive disorder,
Escitalopram should be used cautiously in patients with a history of mania.
Escitalopram Oxalate should be used with caution in patients with a history
of seizure disorder.
Rarely, the occurrence of serotonin syndrome has been reported in patients
A combination of symptoms, possibly including agitation, confusion, tremor,
myoclonus and hyperthermia, may indicate the development of this
The use of citalopram in hepatically impaired patients should be approved
with caution and a lower maximum dosage (10 mg/day) is recommended.
Clinical experience with Escitalopram in patients with concomitant systemic
illness is limited. Escitalopram should be used with caution in diabetic
patients on insulin or other antidiabetic drugs.
The following additional adverse reactions have been reported: agitation or
restlessness, blurred vision, diarrhea, indigestion, nausea, increased or
decreased appetite, increased sweating, sexual difficulties (decreased
sexual ability or desire, ejaculatory delay), taste alterations, tremor (shaking),
USE IN PREGNANCY AND LACTATION
The safety of Escitalopram during pregnancy and lactation has not been
established. Therefore, Escitalopram should not be used during pregnancy,
unless, in the opinion of the physician, the expected benefits to the patients
markedly outweigh the possible hazards to the fetus. Escitalopram is
excreted in human milk. Escitalopram should not be administered to nursing
mothers unless, in the opinion of the treating physician, the expected
benefits to the patient markedly outweigh the possible hazards to the child.
USE IN GERIATRIC PATIENT
Escitalopram pharmocokinetics in subjects age 65 and over were compared
to younger subjects in a single and multi-dose study. No overall differences
in safety or effectiveness between this group and the younger subjects was
observed, but greater sensitivity of some elderly individuals cannot be ruled
out. 10 mg is the recommended dosage for elderly patients.
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