Indication : It is indicated for treatment of the signs and symptoms of osteoarthritis or rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers and their complications.
Dosage and administration : Osteoarthritis: The recommended dosage for maximal GI mucosal protection is Nopain Extra 50 tid. For patients who experience intolerance, Nopain Extra 75 bid or Nopain Extra 50 bid can be used. Rheumatoid Arthritis: The recommended dosage is Nopain Extra 50 tid or qid. For patients who experience intolerance, Nopain Extra 75 bid or Nopain Extra 50 bid can be used. Special Dosing Considerations: Nopain Extra contains misoprostol, which provides protection against gastric and duodenal ulcers. For gastric ulcer prevention, the 0.2mg qid and tid regimens are therapeutically equivalent, but more protective than the bid regimen. Or, as directed by the registered physician.
Use in pregnancy and lactation : In late pregnancy, as with other NSAIDs, this drug should be avoided because it may cause premature closure of the ductus arteriosus.