Different types of anxiety, depression & apathy. These include- psychogenic depression, depressive neuroses, masked depression, psychosomatic affections accompanied by anxiety and apathy, menopausal depressions, dysphoria and depression in alcoholics and drug-addicts.
Combined anxiolytics & anti-depressant drugs
Flupenthixol primarily acts as a neuroleptic drug. The antipsychotic effect of Flupenthixol is achieved by mixed blockade of dopamine D1 and D2 receptors. In the mesolimbic dopamine system of the brain, this accounts for the antipsychotic action of this drug. Flupenthixol has other effects on CNS. In the chemoreceptor trigger zone, the dopamine blockade accounts for the antiemetic effect of the drug.
Melitracen is a tricyclic antidepressant. It blocks the neuronal re-uptake of both serotonin and nor-epinephrine in the central nervous system, there by minimizing the symptoms of depression.
Dosage & Administration
Adults: In general 2 tablets per day, morning and at midday. For the severe cases, the amount of the morning dose can be increased to 2 tablets.
Elderly patients: One tablet in the morning.
Maintenance dose: 1 tablet in the morning. In cases of insomnia or severe restlessness additional treatment with a sedative in acute phase is recommended.
Flupentixol-melitracen may enhance the response to alcohol, barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.
The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow angle glaucoma. Acute alcohol, barbiturate and opiate intoxication. Flupentixol and Melitracen should not be given to patients who have received a MAO inhibitor within two weeks. Not recommended for excitable patient since its activating effect may lead to exaggeration of these characteristics.
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Pregnancy & Lactation
Flupentixol and Melitracen should preferably not be given during pregnancy and lactation.