Levofloxacin is a synthetic, broad-spectrum, third generation fluoroquinolone derivative antibacterial agent. Chemically levofloxacin is a chiral fluorinated carboxyquinolone.
Dosage and administration:
The usual dose of Levoxin Tablets is 250 mg or 500 mg or 750 mg administered orally every 24 hours. Levoxin tablets can be administered without regard to food. Levofloxacin oral solution should be taken 1 hour before, or 2 hours after eating.
Levoxin injection should only be administered by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration. The usual dose of Levoxin injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours. Since the Levoxin injections are for single-use only, any unused portion should be discarded. Additives or other medications should not be added to Levoxin Injection or infused simultaneously through the same intravenous line.
– Acute sinusitis: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days
– Exacerbation of chronic bronchitis: 500 mg once daily for 7 days, or 750 mg once daily for 3 days (Uncomplicated), 750 mg once daily for 5 days (Complicated)
– Community-acquired pneumonia: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days
– Uncomplicated urinary-tract infections: 250 mg once daily for 3 days
– Complicated urinary-tract infections and acute pyelonephritis: 250 mg once daily for 7-10 days
– Uncomplicated skin and soft-tissue infections: 500 mg once daily for 7- 10 days
– Complicated skin and soft-tissue infections: 750 mg once daily for 7-14 days
– Enteric fever: 500 mg once daily for 7-14 days
– Diarrhea, cholera, shigellosis & enteritis:
– – Mild to moderate case: 500 mg (single dose)
– – Moderate to sever case: 500 mg once daily for 3 days
– Children 6 months to <5 years: 10 mg/kg every 12 hours
– Children > 5 years:10 mg/kg every 24 hours
In each case, sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.
Levofloxacin is generally well tolerated. However, a few side-effects can usually be seen. Side-effects include: nausea, vomiting, diarrhea, abdominal pain, flatulence and rare occurrence of phototoxicity ( 0.1%). Side-effects that may be seen very rarely include tremors, depression, anxiety, confusion etc.