- Partial Onset Seizures
- Myoclonic Seizures In Patients with Juvenile Myoclonic Epilepsy
- Primary Generalized Tonic-Clonic Seizures
Levetiracetam injection is an alternative for adult patients (16 years and older) when oral administration is temporarily not feasible.
Studies show that levetiracetam affects intraneuronal Ca levels by partial inhibition of N-type Ca currents and by reducing the release of Ca from intraneuronal stores; facilitates GABA-ergic inhibitory transmission through displacement of negative modulators; reduces delayed rectifier K current; and/or binds to synaptic proteins which modulate neurotransmitter release.
For tablet and oral solution-
Treatment should be initiated with a daily dose of 1000 mg/day, given as twice-daily dosing (500 mg twice daily). Additional dosing increments may be given (1000 mg/day additional every 2 weeks) to a maximum recommended daily dose of 3000 mg.
Use in Pediatric Patients-
- 1 Month To <6 Months: Initial Daily dose 7 mg/kg twice daily & Incremental Daily dose 21 mg/kg twice daily
- 6 Months To <4 Years: Initial Daily dose 10 mg/kg twice daily & Incremental Daily dose 25 mg/kg twice daily
- 4 Years To <16 Years: Initial Daily dose 10 mg/kg twice daily & Incremental Daily dose 30 mg/kg twice daily
- Adolescent with 20-40 kg body weight: Initial Daily dose 250 mg twice daily & Incremental Daily dose 750 mg twice daily
The daily dose should be increased every 2 weeks.