Dosage & Administration
- Regimen 1: 8-12 gm/m2 divided over 3-5 days, repeat course every 2-4 wk.
- Regimen 2: 6 gm/m2 divided over 5 days, repeat course every 3 wk.
- Regimen 3: 5-6 gm/m2 (max: 10 gm), give as a single 24-hr infusion, repeat course every 3-4 wkly.
Germ cell testicular carcinoma: 1.2 gm/m2/day for 5 days via slow infusion over at least 30 minutes, repeat treatment every 3 wk or after recovery from haematological toxicity. To be given with mesna and adequate hydration of at least 2 L of oral or IV fluid per day.
Potentially Fatal: Severe myelosuppression, haemorrhagic cystitis, nephrotoxicity, cardiotoxicity, coma.