Cefuroxime is a semisynthetic, broad-spectrum cephalosporin antibiotic for oral administration.
Respiratory tract infections, for example, acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess. Ear, nose and throat infections, for example, sinusitis, tonsillitis and pharyngitis. Urinary tract infections, for example, acute and chronic pyelonephritis, cystitis. Soft tissue infections, for example, impetigo, cellulitis, erysipelas, peritonitis and wound infections. Gonorrhea. Other infections, including septicaemia, meningitis and Lyme disease.
- Most infections will respond to 250 mg b.i.d. In mild to moderate lower respiratory tract infections e.g. bronchitis 250 mg b.i.d. should be given. For more severe lower respiratory tract infections, or if pneumonia is suspected then 500 mg b.i.d. should be given.
- For urinary tract infections a dose of 125 mg b.i.d. is usually adequate; in pyelonephritis the recommended dose is 250 mg b.i.d.
- Uncomplicated gonorrhoea: A single dose of one gram is recommended for the treatment of uncomplicated gonorrhoea.
- Lyme disease (In adults and children over the age of 12 years): the recommended dose is 500 mg b.i.d. for 20 days.
- The usual dose is 125 mg b.i.d., or 10 mg/kg b.i.d. to a maximum of 250 mg daily.
- For otitis media, in children less than 2 years of age the usual dosage is 125 mg b.i.d., or 10 mg/kg b.i.d. to a maximum of 250 mg daily and in children over 2 years of age, 250 mg b.i.d., or 15 mg/kg b.i.d. to a maximum of 500 mg daily. There is no experience in children under three months of age. The usual course of therapy is seven days.
Adults: 750 mg to 1.5 g IM or IV every 8 hourly, usually 5 to 10 days. Preoperative prophylaxis: For clean contaminated or potentially contaminated surgical procedures, administer 1.5 g IV prior to surgery ( 1 / 2 to 1 hour before). Thereafter, give 750 mg IV or IM every 8 hours when the procedure is prolonged.
Infants and children (>3 months): 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours. Use 100 mg/kg/day (not to exceed the maximum adult dose) for more severe or serious infections.
Bone & joint infections: 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.
Bacterial meningitis: Initially 200 to 240 mg/kg/day IV in divided doses every 6 to 8 hours.