• Essential hypertension
• Chronic congestive heart failure
• Hepatic cirrhosis, with collection of fluid in the abdominal cavity (ascites)
• Swelling due to excess fluid retention (edema)
• Resistant edema associated with secondary hyperaldosteronism
Dosage & Administration
Edeloss: 1 to 4 tablets daily, orally, according to the patient’s response.
Edeloss Plus: For previously stabilized patients 1 to 2 tablets daily, orally.
Generally, this combination preparation is well tolerated. However, a few side effects like nausea, malaise or gastric upset, headache, hypotension, skin rash may be seen which disappears after withdrawal of the drug.
Caution should be taken in patients liable to electrolyte deficiency. This preparation should also be used with caution in diabetes, enlarged prostate, hypotension and in hypovolemia.
The combination of Frusemide and Spironolactone is contraindicated in patients with acute renal failure, renal insufficiency (creatinine clearance: <30ml/min), anuric states, hyperkalemia, hyponatremia, addison’s disease or in patients with hypersensitivity to Frusemide, Spironolactone or Sulphonamide. It is also contraindicated for children.
Use in Pregnancy & Lactation
Pregnancy: There is clinical evidence of safety of Frusemide in pregnancy but Spironolactone may cross the placental barrier. So it should be used in pregnancy only if strictly indicated & for short-term treatment and if expected benefits to the mother is greater than the possible risk to the fetus.
Lactation: It is contraindicated in lactating mother.