Diosmin and Hesperidin is a phlebotonic drug and a vascular protecting agent. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus Diosmin and Hesperidin decreases venous capacitance, venous distensibility, and venous emptying time.
Diosmin and Hesperidin protects the microcirculation by fighting the microcirculation damaging process; It combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandin. Thus Diosmin and Hesperidin normalizes capillary permeability and strengthens capillary resistance.
Diosmin and Hesperidin acts on the lymphatic system, It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure.
Dosage & Administration
- Acute attack: 6 tablets daily for the 1st 4 days followed by 4 tablets daily for the next 3 days.
- Chronic haemorrhoids: 2 tablets daily.
Chronic venous disease: 2 tablets daily. The tablets should be taken at meal times.
Pregnancy & Lactation
Lactation: In the absence of data concerning the diffusion of the drug substance in the breast milk, breast feeding is not recommended during treatment.