- Allergy and anaphylaxis: bronchial asthma, drug hypersensitivity reactions, serum sickness, angioneurotic oedema, anaphylaxis.
- Respiratory disease: allergic pneumonitis, asthma, occupational asthma, pulmonary aspergillosis, pulmonary fibrosis, pulmonary alveolitis, aspiration of foreign body, aspiration of stomach contents, pulmonary sarcoid, drug induced lung disease, adult respiratory distress syndrome, spasmodic croup.
- Rheumatic disorders: rheumatoid arthritis, polymyalgia rheumatica, juvenile chronic arthritis, systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease.
- Arteritis/collagenosis: giant cell arteritis/polymyalgia rheumatica, mixed connective tissue disease, polyarteritis nodosa, polymyositis.
- Blood disorders: haemolytic anaemia (auto-immune), leukaemia (acute and chronic lymphocytic), lymphoma, multiple myeloma, idiopathic thrombocytopenic purpura.
- Cardiovascular disorders: post-myocardial infarction syndrome, rheumatic fever with severe carditis.
- Endocrine disorders: primary and secondary adrenal insufficiency, congenital adrenal hyperplasia.
- Gastro-intestinal disorders: Crohn’s disease, ulcerative colitis, persistent coeliac syndrome (coeliac disease unresponsive to gluten withdrawal), auto-immune chronic active hepatitis, multisystem disease affecting liver, biliary peritonitis.
- Infections (with appropriate chemotherapy): helminthic infestations, Herxheimer reaction, infectious mononucleosis, miliary tuberculosis, mumps orchitis (adult), tuberculous meningitis, rickettsial disease.
- Muscular disorders: polymyositis, dermatomyositis.
- Neurological disorders: infantile spasms, Shy-Drager syndrome, sub-acute demyelinating polyneuropathy.
- Ocular disease: scleritis, posterior uveitis, retinal vasculitis, pseudo-tumours of the orbit, giant cell arteritis, malignant ophthalmic Graves disease.
- Renal disorders: lupus nephritis, acute interstitial nephritis, minimal change glomerulonephritis.
- Skin disorders: pemphigus vulgaris, bullous pemphigoid, systemic lupus erythematosus, pyoderma gangrenosum.
- Miscellaneous: sarcoidosis, hyperpyrexia, Behçets disease, immunosuppression in organ transplantation.
Dosage & Administration
General dosage guidelines : The initial dosage of Cortisol may vary from 5 mg to 60 mg daily depending on the disorder being treated. Divided daily dosage is usually used. The appropriate individual dose must be determined by trial and error and must be re-evaluated regularly according to activity of the disease. In general, initial dosage shall be maintained or adjusted until the anticipated response is observed. The dose should be gradually reduced until the lowest dose, which will maintain an adequate clinical response is reached. During prolonged therapy, dosage may need to be temporarily increased during periods of stress or during exacerbations of the disease.
Intermittent dosage regimen: A single dose of Cortisol in the morning on alternate days or at longer intervals is acceptable therapy for some patients. When this regimen is practical, the degree of pituitary-adrenal suppression can be minimised. Specific dosage guidelines: Allergic and skin disorders: Initial doses of 5-15 mg daily are commonly adequate. Collagenosis: Initial doses of 20-30 mg daily are frequently effective. Those with more severe symptoms may require higher doses. Rheumatoid arthritis: The usual initial dose is 10-15 mg daily. The lowest daily maintenance dose compatible with tolerable symptomatic relief is recommended. Cheap christian louboutin for sale. Blood disorders and lymphoma: An initial daily dose of 15-60 mg is often necessary with reduction after an adequate clinical or haematological response. Higher doses may be necessary to induce remission in acute leukaemia.
Dosage for Children:
|General dosage||0.14-2 mg/kg/day in three to four divided doses|
for 3-10 days
|Asthma||1-2 mg/kg/day in single or divided doses|
|Nephritic syndrome||2 mg/kg/day in three to four divided doses for4 weeks followed by 4 weeks of single dosealternate day therapy at 1 mg/kg/day|
|Treatment of rheumatoid arthritis||7.5 mg dai|
General side-effects include leucocytosis, hypersensitivity including anaphylaxis, thromboembolism and nausea.
Systemic infections unless specific anti-infective therapy is employed. Hypersensitivity to any ingredient. Ocular herpes simplex because of possible perforation.