Cefuroxime is indicated in the treatment of:
Upper respiratory tract infections: for example, ear, nose and throat infections such as otitis media, sinusitis, tonsillitis and pharyngitis.
Lower respiratory tract infections: for example, acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia.
Skin and soft tissue infections: such as furunculosis, pyoderma, and impetigo.
Genito-urinary tract infections: such as pyelonephritis, urethritis, and cystitis.
Gonorrhoea: acute uncomplicated gonococcal urethritis, and cervicitis.
Early Lyme disease & subsequent prevention of late Lyme disease.
Second generation Cephalosporins
Cefuroxime is a well-characterized and effective antibacterial agent, which has broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains. Cefuroxime has good stability to bacterial β-lactamase and consequently, is active against many ampicillin-resistant and amoxycillin-resistant strains.
Most infections will respond to 250 mg b.i.d. In mild to moderate lower respiratory tract infections e.g. bronchitis 250 mg b.i.d. should be given. For more severe lower respiratory tract infections, or if pneumonia is suspected then 500 mg b.i.d. should be given.
For urinary tract infections a dose of 125 mg b.i.d. is usually adequate; in pyelonephritis the recommended dose is 250 mg b.i.d.
Uncomplicated gonorrhoea: A single dose of one gram is recommended for the treatment of uncomplicated gonorrhoea.
Lyme disease (In adults and children over the age of 12 years): the recommended dose is 500 mg b.i.d. for 20 days.
The usual dose is 125 mg b.i.d., or 10 mg/kg b.i.d. to a maximum of 250 mg daily.
For otitis media, in children less than 2 years of age the usual dosage is 125 mg b.i.d., or 10 mg/kg b.i.d. to a maximum of 250 mg daily and in children over 2 years of age, 250 mg b.i.d., or 15 mg/kg b.i.d. to a maximum of 500 mg daily. There is no experience in children under three months of age. The usual course of therapy is seven days.
Adults: 750 mg to 1.5 g IM or IV every 8 hourly, usually 5 to 10 days. Preoperative prophylaxis: For clean contaminated or potentially contaminated surgical procedures, administer 1.5 g IV prior to surgery ( 1 / 2 to 1 hour before). Thereafter, give 750 mg IV or IM every 8 hours when the procedure is prolonged.
Infants and children (>3 months): 50 to 100 mg/kg/day in equally divided doses every 6 to 8 hours. Use 100 mg/kg/day (not to exceed the maximum adult dose) for more severe or serious infections.
Bone & joint infections: 150 mg/kg/day (not to exceed the maximum adult dose) in equally divided doses every 8 hours.
Bacterial meningitis: Initially 200 to 240 mg/kg/day IV in divided doses every 6 to 8 hours.
Cefuroxime should be taken after food for optimum absorption.
No potentially hazardous interactions have been reported.
Cefuroxime is contraindicated in patients with known allergy to Cephalosporins.
Cefuroxime has been associated with nausea and vomiting in a small number of patients.