Indication and usage
® is indicated for the treatment of upper and lower respiratory tract infections.
Urinary tract infections, gonococcal urethritis, typhoid fever & acutee otitis media.
Clinical efficacy has been demonstrated in infections caused by commonly occurring pathogens
including Stretococcus pneumoniae, Streptococcus pyogenes, Escherechia coli, Proteus mirabilis,
Klebsiella species, Hemophyllus influenzae (β-lactamase positive and negative), Moraxella
catarrhalis (β-lactamase positive and negative), and Enterobacter species. Cefixime is highly
stable in the presence of β-lactamase enzymes.
Dosage and administration
The usual duration of treatment of Cefixime is 7 days. This may be continued for up to 14 days.
Adult and children over 10 years : 200-400mg daily as a single dose or in 2 divided doses
Child over 6 months : 8 mg/ kg daily as a single dose or in 2 divided doses
Child 6 months – 1 year : 75 mg daily or 3.75ml
Child 5-10 years : 200 mg daily
Pregnancy and Lactation
Reproduction studies was performed in mice and rats at doses up to 400 times the human dose
and revealed no evidence of impaired fertility or harm to the foetus due to Cefixime.
There are no adequate and well controlled studies in pregnant women. Therefore, Cefixime
should not be used in pregnancy or in nursing mothers unless considered essential by the
Cefixime generally well tolerated. The majority of adverse reactions observed in clinical trials
were mild and self limiting in nature. Among them diarhoea, dyspepsia, headache, dizziness,
elevation of serum amylase may occur.
Patients with known hypersensitivity to Cephalosporin group drugs.
Cefixime should be prescribed with caution in individuals with a history of gastrointestinal
diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure.
In common with other Cephalosporins, increases in prothrombin times have been noted in a few
patients. Care should therefore be taken in patients receiving anticoagulant therapy. A false
positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solutions or with
copper sulphate lest tablets, but not with test based on enzymatic glucose oxidase reactions.