Avlomox® 250mg Capsules: Yellow body and maroon cap, both cap and body
imprinted with either ‘AVLOMOX’ or ‘ACI’. Each capsule contains Amoxycillin 250mg
as Trihydrate BP.
Avlomox® 500mg Capsules: Black body and red cap, both cap and body imprinted
with either ‘AVLOMOX 500’ or ‘ACI’. Each capsule contains Amoxycillin 500mg as
Avlomox® Powder for Suspension 125mg/5ml: Bottles containing powder for the
preparation of 100ml white coloured, banana flavoured suspension; when
reconstituted each 5ml contains Amoxycillin 125mg as Trihydrate BP.
Avlomox® DS Powder for Suspension 250mg/5ml: Bottles containing
powder for the preparation of 100ml/60ml white coloured, banana flavoured
suspension; when reconstituted each 5ml contains Amoxycillin 250mg as Trihydrate
Avlomox® Paediatric Drops: Bottles containing powder for the preparation of 15ml of
white coloured, banana flavoured suspension; when reconstituted each 1.25ml
contains Amoxycillin 125mg as Trihydrade BP.
Avlomox® 500mg Injection: Vials containing Amoxycillin 500mg as Sodium BP;
presented as powder for reconstitution.
Avlomox® is a broad spectrum antibiotic indicated in a wide range of infections
caused by susceptible Gra
Skin and soft tissue infections: Cellulitis, infected wounds, carbuncles, furunculosis,
Venereal infections: Gonorrhoea, syphilis.
Prophylaxis of endocarditis: Avlomox® may be used for the prevention of
bacteremia, associated with procedures such as dental extraction, in patients at risk
of developing bacterial endocarditis.
Dosage and administration
Adults (including elderly patients): Oral : 250mg three times daily, increasing to
500mg three times daily for more severe infections.
Injectable: 500mg IM eight hourly (or more frequently if necessary) in moderate
infections. (This dose may be given by slow IV injection if more convenient).1g IV six
hourly in severe infections.
Children: Oral: Upto 10 years of age: 125mg three times daily, increasing to 250mg
three times daily for more severe infections.
Under 2 years of age: 1/4 of the adult dose.
Injectable: 50 – 100mg/kg body weight IM or IV (depending on the severity) in
three to four equal divided doses.
Specific dosage recommendations:
Acute cystitis/Bacteriuria: A single dose of 3g.
Typhoid and Paratyphoid: Adult dosage: 4g daily in divided doses for 14-21 days.
Children dosage: 100mg/kg bodyweight daily in divided doses for 14-21 days.
Typhoid carrier states: 3-4g daily in divided doses for a minimum of 1 month.
Gonorrhoea: A single dose of 3g.
Syphilis : A dosage of 250mg every 6 hours has been used in all stages of syphilis.
Duration of treatment varied from 4 weeks upto 5 months according to serological
Simple acute urinary tract infection: Two 3g doses with10-12 hours between the
Dental abscess: Two 3g doses with 8 hours between the doses.
Severe or recurrent acute otitis media: 3 to 10 years : 750mg twice a day for two
days may be used as an alternative course of treatment.
Prophylaxis of Endocarditis: Adults: 3g orally,1 hour before and 6 hours after dental
procedure. Children: 1/2 of the adult dose. Patients with prosthetic heart valves or
with a history of endocarditis will require gentamicin in addition.
Intravenous: Dissolve 500 mg in 10ml Water for Injection BP.
Avlomox® Injection, suitably diluted, may be injected directly into a vein or the
infusion line over a period of 3-4 minutes.
Intravenous Infusion: Solutions may be prepared as described for intravenous
injections and then added to an intravenous solution in a minibag or in-line burette
and administered over a period of 1/2-1 hour. Alternatively, using a suitable
reconstitution device, the appropriate volume of intravenous fluid may be transferred
from the infusion bag into the vial and then drawn back into the bag after
500mg: Add 2.5ml Water for Injections BP and shake vigorously.
If pain is experienced on intramuscular injection, a sterile 1% solution of lignocaine
hydrochloride or 0.5% solution of procaine hydrochloride may be used in place of
water for injections.
A transient pink colouration or slight opalescence may appear during reconstitution.
Reconstituted solutions are normally a pale straw colour.
Contra-indications, warnings, etc.
Contra-indications: Penicillin hypersensitivity.
Use in pregnancy and lactation: Animal studies with Amoxycillin have shown no
teratogenic effects. It’s suitability in human pregnancy has been well documented in
clinical studies. When antibiotic therapy is required during pregnancy, Amoxycillin
may be considered appropriate. During lactation, trace quantities of Amoxycillin can
be detected in breast milk.
Side-effects: Side-effects as with other penicillins, are uncommon and mainly of a
mild and transitory nature; they may include diarrhoea, indigestion, or occasionally
rash, either urticarial or erythematous. In common with other beta-lactam antibiotics
angioedema and anaphylaxis have been reported.
Overdosage: Gross overdosage will produce very high urinary concentrations.
Problems are unlikely if adequate fluid intake and urinary output are maintained;
however, crystalluria is a possibility. More specific measures may be necessary in
patients with impaired renal function, the antibiotic is removed by hemodialysis.
Store in a cool, dry place.
Avlomox® DS, Avlomox® Powder for Suspension and Avlomox® paediatric drops
should be freshly prepared.
Prepared Suspension is to be consumed within 7 days of preperation.
When prepared for intramuscular or direct intravenous injections, Avlomox® should
be administered immediately after reconstitution. The stability of Avlomox® in
various infusion fluids is dependent upon the concentration and temperature.
Avlomox® should not be mixed with blood products, other proteinaceous lipid
If Avlomox® is prescribed concurrently with aminoglycoside the antibiotics should
not be mixed in the syringe, intravenous fluid container or giving set because loss of
activity of the aminoglycoside can occur under these conditions.
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