Pyridoxine Hydrochloride (Vit – B6), either alone or combination has been used to prevent nausea & vomiting due to its antiemetic properties.
Dosage & Administration
Nausea & vomiting (including morning sickness in pregnancy): One tablet 1-2 times daily.
Motion sickness: One or two tablets one hour prior to journey. The dose may be repeated every 24 hours as indicated for the duration of journey.
Vertigo: One tablet 2 times daily or as directed by physician.
Labyrinthine and vestibular disturbances: The optimal dose of Meclizine Hydrochloride is usually 25 to 100 mg daily in divided doses, depending on the clinical response.
Radiation sickness: 50 mg (Meclizine Hydrochloride) administered 2 to 12 hours prior to radiation treatment. Pyridoxine Hydrochloride (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
Pregnancy & Lactation
Use in lactation: Meclizine may be distributed into breast milk. However problem in human have not been documented. On the other hand, Pyridoxine has no adverse effects during lactation.