Dosage & Administration
Pregnancy & Lactation
Impairment in Renal Function: Monitor renal function during therapy. More frequent monitoring is recommended in patients with eGFR below 60 mL/min/1.73 m2. Do not initiate Canagliflozin if eGFR is below 45 mL/min/1.73 m2.
Hyperkalemia: Monitor potassium levels in patients with impaired renal function and in patients predisposed to hyperkalemia.
Hypoglycemia: Consider a lower dose of insulin or the insulin secretagogue to reduce the risk of hypoglycemia when used in combination with Canagliflozin.
Use in Special Population
Geriatric Uses: Patients 65 years and older had a higher incidence of adverse reactions related to reduced intravascular volume with Canagliflozin (such as hypotension, postural dizziness, orthostatic hypotension, syncope, and dehydration).