Calbo® 500 : Each tablet contains Calcium Carbonate BP 1.25 gm
equivalent to 500 mg of Calcium.
Calcium carbonate reacts with gastric acid to produce a salt and water. For
calcium carbonate the postulated chemical reaction is :
CaCO3 + 2HCl = CaCl2 + H2O + CO2
Two grams of calcium carbonate will readily bring 100 ml of hydrochloric
acid to a pH above 6. The increase in gastric pH diminishes the activity of
pepsin in the gastric secretion. Up to 30% of the oral calcium load may be
Calbo® 500 (Calcium Carbonate) is used for the treatment or prevention of
calcium depletion in patients in whom dietary measures are inadequate.
Conditions that may be associated with calcium deficiency include
hypoparathyroidism, achlorhydria, chronic diarrhea, vitamin D deficiency,
steatorrhea, sprue, pregnancy and lactation, menopause, pancreatitis, renal
failure, alkalosis, and hyperphosphataemia. Calcium Carbonate is being
used increasingly often to treat hyperphosphataemia in chronic renal failure
as well as those on continuous ambulatory peritoneal dialysis (CAPD) and
haemodialysis. Many patients are unable to tolerate sufficient doses for
complete phosphate control and require additional measures such as
stringent dietary phosphate restriction or relatively small doses of aluminium
hydroxide. Calcium Carbonate containing preparations can provide shortterm
relief of dyspeptic systems but are no longer recommended for longterm
treatment of peptic ulceration.
DOSAGE AND ADMINISTRATION:
Calcium Carbonate is always used orally and when used as an antacid the
recommended doses for adults are equivalent to 540-2000 mg Calcium
Carbonate per day, doses for children being half of those for adults. As a
dietary supplement, such as for the prevention of osteoporosis, 1250-3750
mg Calcium Carbonate (500-1500 mg calcium) daily is recommended in
general, but again this will need to be tailored to the individual patient
depending on any specific disease such as Calcium deficiency,
malabsorption or parathyroid function. In pregnancy and lactation the
recommended daily dose of calcium is 1200-1500 mg. In chronic renal
failure the doses used vary from 2.5 – 9.0 gm Calcium Carbonate per day and
need to be adjusted according to the individual patient. To maximize
effective phosphate binding in this context the Calcium Carbonate should
be given with meals.
Orally administered Calcium Carbonate may be irritating to the GI tract. It
may also cause constipation. Hypercalcaemia is rarely produced by
administration of calcium alone, but may occur when large doses are given
to patients with chronic renal failure.
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